While Margo Manhattan developed an appreciation for beauty from her NYCB ballerina mother Karin von aroldingen, it was her father Morty who taught her the importance of charity and giving back to others. Over the years, Margo's philanthropic side and her passion for helping others has taken the form of symbolic, groundbreaking designs. First the Earth pin for Earth Day, 1990. Following on the heels of her universally recognized Red Ribbon lapel pin for AIDS awareness. Margo went onto develop the Pink Ribbon for Breast Cancer for Estée Lauder and for other breast cancer fundraising efforts. Today, these ribbons remain the international icons for AIDS awareness and the Breast Cancer fundraising Research Foundation.

Margo extended this philanthropic vision by adapting the Noguchi Lyre pin for the New York City Ballet; to honor the memory of her late godfather George Balanchine, she designed the commemorative Celebration pin. Then, in collaboration with Mrs. Avery Fisher, she created the Ovarian Cancer Research Foundation pin. Margo brought the world her Meridian Bracelet in order to benefit the Samuel Waxman Cancer Research Foundation: each bracelet is fashioned in the shape of a healthy cell and thus encourages wearers to envision more healthy cells for both themselves and loved ones.